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Heat Shock Protein 40 (HSP40) information database. A resource for all HSP40 structure, isoform, function, disease relevance, and inhibitor information.
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Heat Shock Protein 27 (HSP27) information database. A resource for all HSP27 structure, isoform, function, disease relevance, and inhibitor information.
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Heat Shock Protein 70 (HSP70) information database. A resource for all HSP70 structure, isoform, function, disease relevance, and inhibitor information.
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Introduction - HSP47 | HSP47
Hsp47, also known as Serpin H1, is an ER-resident procollagen-specific molecular chaperone essential for the biosynthesis and structural assembly of collagen 1-3. Beside its role in collagen biosynthesis, Hsp47 represents an essential factor in the mammalian Golgi stress response 4. Hsp47 belongs to clade H of the SERPIN superfamily of proteinase inhibitors, but it does …
Introduction - Alpha Synuclein | Alpha Synuclein
Alpha synuclein is a key protein implicated in Parkinson's Disease, a common neurological disorder. Parkinson's can be inherited or sporadic.
Introduction - Heme Oxygenase | Heme Oxygenase
The heme oxygenases (HOs) are key enzymes in the oxidative degradation of heme to biliverdin (biliverdin IXα), carbon monoxide (CO), and ferrous iron (Fe2+) 1. In mammals, two main isoforms are expressed: HO-1 (also known as Hsp32) and HO-2. While HO-2 is constitutively expressed under basic requirements in the majority of human tissues, HO-1 represents …
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Introduction - GRP78 | GRP78
The 78 kDa glucose-regulated protein 78 (Grp78), also known as immunoglobulin heavy-chain binding protein or binding-immunoglobulin protein (BiP), is a multifunctional protein which belongs to the huge HSP70 family of molecular chaperones 1, 2. Grp78/BiP is constitutively expressed in the ER lumen where it assists in ER proteostasis which is critically involved in the folding …
Introduction - DNA Damage
DNA damage is any modification in DNA structure that alters its physical, chemical and/or structural properties, impacting genomic stability.
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